Precision Nutrition · Broad-Spectrum β-Mannanase

MANNTERIX Punlock trapped energy.

Broad-spectrum β-mannanase. Fewer anti-nutrients. More energy from every tonne.

A high-activity, broad-spectrum β-mannanase engineered for modern poultry nutrition. It hydrolyzes the anti-nutritional mannans in soybean, palm kernel, copra, guar, and canola meal — releasing energy that would otherwise pass through undigested and easing the immune burden that quietly erodes feed conversion.

Broad-spectrum β-Mannanase · GH5 endo-mannanase
Activity ≥ 500,000 MU/g
pH range 3.0–7.0Full GI-tract active
Pelleting Stable to 85 °CThermophilic-derived
Inclusion 100 g/MTComplete feed
Species PoultryBroiler · layer

Why supplement mannanase — three costs that compound.

β-Mannans are anti-nutritional fibers naturally present in soybean meal, palm kernel meal, copra meal, guar meal, and canola meal. Poultry produce little or no endogenous mannanase, so these fibers pass through largely undigested — trapping nutrients, raising viscosity, and triggering an avoidable immune response.

0enzyme
Endogenous mannanase deficit

Birds can't break it down

Poultry produce little to no endogenous mannanase. Without supplementation, dietary β-mannans transit the gut undigested — the nutrients bound behind them never enter the metabolizable pool.

viscosity
Digesta transit

Nutrients get trapped

Undigested β-mannans increase intestinal digesta viscosity, slowing nutrient transit and absorption and reducing the digestibility of the whole diet — not just the mannan fraction.

FIIA
Feed-induced immune activation

Energy diverted from growth

Soluble mannans trigger an innate immune response the bird doesn't need. Every gram of energy spent on that avoidable response is a gram not converted to body weight.

The dietary β-mannan load — higher than most formulators assume.

Even standard corn/soy diets carry a meaningful β-mannan burden, and high-mannan ingredients like guar meal and palm kernel meal push it well past 0.6%. That load is the addressable target for MANNTERIX P.

Typical soluble β-mannan load by diet type

Percent of diet, as-fed — the addressable anti-nutrient MANNTERIX P targets

Corn/soy Starter–Grower 0.43–0.5%
Corn/soy Finisher 0.25–0.35%
High-mannan (guar / palm kernel meal) >0.6%

How it works — mannans to mannan oligosaccharides.

MANNTERIX P hydrolyzes β-mannans into smaller mannan oligosaccharides (MOS). Nutrient digestibility improves, intestinal viscosity drops, and the freed energy — plus the energy no longer spent on immune activation — is redirected to growth.

Substrate breadth — one enzyme, every mannan source.

Diets rarely contain a single, uniform mannan. MANNTERIX P is a broad-spectrum GH5 endo-mannanase that acts across the diverse mannan chemistries found in soy, palm kernel, copra, guar, and canola meal — recording the highest measured activity of three products tested on four of five substrate types.

Head-to-head activity
4 of 5

Highest activity across substrates

Highest measured activity (U/g substrate) of MANNTERIX P, Competitor B, and Competitor A on four of five mannan substrate types tested.

Carob galactomannan
+72%

Advantage on high-viscosity mannan

A 72% activity advantage over Competitor B on carob galactomannan — the high-viscosity substrate that most burdens digesta transit.

Broad substrate action
5

Mannan sources covered

Active across the mannans in soybean, palm kernel, copra, guar, and canola meal — matching the mixed ingredient reality of commercial diets.

Head-to-head substrate activity figures are drawn from supplier documentation shared with KYNAD, not from KYNAD testing. Comparator products are anonymised. Actual activity varies with substrate source, assay conditions, and diet composition.

Stability profile — active from feed mill to gut.

MANNTERIX P is derived from a thermophilic cellulolytic bacterium, giving it intrinsic thermostability through pelleting and broad pH activity across the whole digestive tract. It survives the acidic, protease-rich stomach where competitor enzymes collapse.

Catalytic activity — digestive pH

Retains >80% activity across pH 3.0–7.0

Pepsin resistance — pH 3.0

Activity recovery over 90 min of pepsin exposure

Thermostability — recovery after pelleting at 85 °C

Relative recovery of enzyme activity post-pelleting

MANNTERIX P Intrinsic thermophilic-derived stability
83%
Competitor A Competitor
84%
Competitor B Competitor
53%

MANNTERIX P maintains 84–100% relative activity across the physiological pH range and recovers 75% of activity after 90 minutes of pepsin exposure at pH 3.0 — nearly 3× the pepsin resistance of Competitor A. Comparator figures are drawn from supplier documentation shared with KYNAD, not from KYNAD testing; full detail available in the datasheet on request.

Trial data — performance held under energy reduction.

In a 3-arm broiler trial, dropping dietary energy by 100 kcal/kg cost body weight and FCR. Adding MANNTERIX P to the reduced-energy diet restored body weight above the full-energy standard and delivered the best FCR of all three treatments.

Energy-reduction broiler trial · D0–D42

KYNAD trial 3 diets · body weight & FCR at 21 and 42 days
Design. Three diets — Standard energy, Reduced Energy (−100 kcal/kg), and Reduced Energy + MANNTERIX P at 100 g/MT. Body weight (g/bird) and FCR recorded at Day 21 and Day 42.
Diet BW @ 21d (g) FCR @ 21d BW @ 42d (g) FCR @ 42d
Standard 873 1.32 2,890 1.72
Reduced Energy (−100 kcal/kg) 862 1.34 2,790 1.76
MANNTERIX P (−100 kcal/kg) 883 1.30 2,875 1.70

Interpretation. At −100 kcal/kg, MANNTERIX P restored body weight above the standard-energy diet at 21 days (883 vs 873 g/bird) and delivered the best FCR of all three treatments at both 21 and 42 days — recovering the full energy reduction and then some.

Confirmed growth and efficiency — a separate 4-arm trial.

A second broiler trial (n=6) confirmed the effect. Adding 100 g/MT MANNTERIX P to a diet reduced by 100 kcal/kg produced the highest average daily gain and the best FCR of any treatment — beating even the full-energy positive control.

4-arm broiler trial · ADG & FCR

KYNAD trial · n=6 means; superscript letters mark P<0.05
Treatment ADG (g/bird/day) FCR
Positive Control (PC) 67.01 1.518
PC + 100 g MANNTERIX P 67.65 1.488
PC − 100 kcal/kg (reduced energy) 67.15 1.550
PC − 100 kcal + 100 g MANNTERIX P 68.33 1.458

Interpretation. The reduced-energy diet with MANNTERIX P produced the highest ADG (68.33 g/bird/day) and the best FCR (1.458) of any treatment — outperforming the full-energy positive control (67.01 g/bird/day, FCR 1.518).

Values are means (n=6); different superscript letters indicate significant differences (P<0.05) in the source trial. Actual outcomes vary by operation, breed, feed formulation, and dietary mannan level.

Head-to-head — outperforms leading competitor enzymes.

Across head-to-head broiler trials, MANNTERIX P outperformed Competitor A on ADG and matched it on FCR at 21 days, and outperformed Competitor B on both FCR and ileal digestibility at 28 days — the largest digestibility gain of the three treatments.

Trial metric Control MANNTERIX P Competitor
ADG @ 21d, g/bird/day · vs Competitor A 30.5 32.2 29.6
FCR @ 21d · vs Competitor A 1.36 1.35 1.36
FCR @ 28d · vs Competitor B 1.52 1.46 1.50
Ileal digestibility @ 28d, % · vs Competitor B 54 61 57

Interpretation. MANNTERIX P delivered a +7-point ileal digestibility gain over control at 28 days — the largest of the three treatments — and the lowest FCR in both comparisons.

Beyond feed conversion — a healthier gut.

Lower digesta viscosity and fewer intestinal lesions point to a lower-inflammation, higher-throughput gut. This complements the pathogen control delivered by KYNAD's PHAGIX™ platform — together supporting a more resilient gut environment.

−18% Digesta viscosity in corn/soybean-meal diets 1.8 cP with MANNTERIX P vs 2.2 cP for control — easing nutrient transit and absorption.
−73% Intestinal lesion score at 42 days 0.3 with MANNTERIX P vs 1.1 for control at 42 days, and 74% lower at 21 days (0.5 vs 1.9) — a healthier, more resilient gut.
Stacks with the microbiome platform. MANNTERIX P's reduction in viscosity and lesion scores complements the pathogen control of PHAGIX™ and the gut-integrity support of QUILLIX™ — together lowering inflammation and lifting throughput across the D14–D35 window.

Return on investment — two paths to value.

MANNTERIX P at 100 g/MT delivers value two ways: as a direct FCR improvement on the existing formula, or as energy-matrix headroom that lets the nutritionist pull cost out by partially replacing corn and fat.

$6–12 Feed cost saving per MT · FCR path A 3–6 point FCR improvement on the existing formula, worth ≈ US$6–12 per MT of feed consumed (illustrative, at FCR 1.6 and feed cost US$300/MT).
$8–16 Feed cost saving per MT · energy-matrix path Supports a 50–100 kcal/kg energy reduction by partially replacing corn and fat, worth ≈ US$8–16 per MT depending on ingredient prices.

Illustrative ROI model — actual savings vary by feed formulation, ingredient cost, and regional pricing. Figures assume FCR 1.6 and a feed cost of US$300/MT.

Dosing — one simple inclusion rate.

MANNTERIX P ships as a single powder form with one straightforward inclusion rate across poultry programs. Apply on top for an FCR gain, or take the energy-matrix credit in reformulation.

100g/MT
Standard inclusion

On-top application

Added to the existing formula to capture the 3–6 point FCR improvement and gut-health benefit without reformulating.

Broiler100 g/MT feed
Layer100 g/MT feed
100g/MT
Energy-matrix credit

Reformulation

Same inclusion, taken as a 50–100 kcal/kg energy credit — partially replacing corn and fat to pull cost out of the formula.

Energy credit50–100kcal/kg
High-mannan diets100 g/MT feed

Actual inclusion and matrix credit may vary with feed formulation, mannan load, and production objectives. The KYNAD technical team provides species- and diet-specific tuning for starter, grower, and finisher programs.

Specifications.

Complete product specifications for MANNTERIX P™ broad-spectrum β-mannanase. Certificate of analysis and SDS available on request.

Product typeBroad-spectrum β-mannanase feed enzyme
ActiveBacterial GH5 endo-mannanase · activity ≥ 500,000 MU/g
SourceThermophilic cellulolytic bacterium (intrinsic thermostability)
FunctionHydrolysis of dietary β-mannans → mannan oligosaccharides (MOS)
FormPowder
pH activity range3.0–7.0 · >80% activity retained (full GI-tract coverage)
Pepsin resistance75% activity recovery after 90 min at pH 3.0
Thermal stabilityStable at pelleting temperatures up to 85 °C · 83% recovery
SpeciesPoultry (broiler & layer)
Inclusion rate100 g/MT of complete feed
Energy-matrix credit~50–100 kcal/kg dietary energy (formulation-dependent)
Target substratesβ-mannans in soybean, palm kernel, copra, guar & canola meal
StorageCool, dry, well-ventilated · avoid sunlight & moisture · reseal after opening
Activity ≥ 500,000 MU/gPer release spec
pH range 3.0–7.0>80% retained
Thermostability 85 °C pelleting83% recovery
Pepsin resistance 75% @ 90 minpH 3.0
Inclusion 100 g/MTComplete feed
Request

Request the full MANNTERIX P™ packet.

Product specification sheet, certificate of analysis, broiler trial summaries, and the MANNTERIX P™ Introduction Book — a technical brief covering mannan chemistry, mechanism of action, substrate breadth, stability profiles, and feed-cost optimization.